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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in
《医学前沿（英文）》 页码 939-956 doi: 10.1007/s11684-023-0987-9
关键词： mononuclear diploid cardiomyocytes cell–cell communication cardiac fibroblast single-cell RNA sequencing cardiac regeneration
Integrated management of cardiac failure: the cardiac failure clinic
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《医学前沿（英文）》 2011年 第5卷 第1期 页码 20-25 doi: 10.1007/s11684-011-0106-1
The prevalence of the risk factors and the risk of cardiac failure are both increasing in China. This might be the consequence of the changes of the life conditions (emigration to the urban areas, changes in the diet and life style, lack of physical exercise, etc.). The wide range of clinical presentations of cardiac failure (acute or chronic) and of therapeutic approaches (medical or surgical) makes necessary the integration within the same structure of the various experts involved in the diagnosis and the treatment of cardiac diseases. Technologic and human resources required to offer all the options represent a multifaceted commitment which should be focused optimally in dedicated centers. In these centers, collaboration should replace competition between the medical and the surgical cardiac specialists. Development of team work should permit to optimize the cost efficacy of the treatments. Most of all, such a structure will facilitate the translation of innovative therapies between the research centers and clinical facilities.
关键词： cardiac failure cardiac transplantation mechanical circulatory support
《医学前沿（英文）》 2023年 第17卷 第1期 页码 58-67 doi: 10.1007/s11684-022-0937-y
关键词： cardiac disease mortality aged population lung transplantation
Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock
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《医学前沿（英文）》 2014年 第8卷 第2期 页码 254-258 doi: 10.1007/s11684-014-0319-1
Mantle cell lymphoma is an aggressive subtype of B cell non-Hodgkin lymphoma. It can progress to leukemic phase but frank leukemic picture at initial presentation is not common. Leukemic phase indicates advance stage of the disease and generally associated with extensive extra-nodal involvement. Pericardial invasion has been reported, however we could not find a report of myocardial infiltration by this disease since the appraisal of the term “mantle cell lymphoma” in 1992. Here we report a case of cardiac involvement by mantle cell leukemia leading to cardiogenic shock which complicates the treatment decisions.
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
《医学前沿（英文）》 2008年 第2卷 第1期 页码 19-24 doi: 10.1007/s11684-008-0005-2
关键词： therapy Sprague administration cardiac hypertrophy valsartan
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《医学前沿（英文）》 2014年 第8卷 第4期 页码 445-455 doi: 10.1007/s11684-014-0378-3
Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis. We assessed cardiac fibrosis and pathology in mice subjected to transverse aortic constriction (TAC). Oral sildenafil, a PDE5 inhibitor, was administered in the therapy group. In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiac fibroblast activation (proliferation and transformation to myofibroblasts). Sildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiac fibroblast activation but did not block TAC-induced transforming growth factor-β1 (TGF-β1) production and phosphorylation of Smad2/3. In isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformation, proliferation and collagen synthesis. Furthermore, we found that sildenafil induced phosphorylated cAMP response element binding protein (CREB) and reduced CREB-binding protein 1 (CBP1) recruitment to Smad transcriptional complexes. PDE5 inhibition prevents cardiac fibrosis by reducing CBP1 recruitment to Smad transcriptional complexes through CREB activation in cardiac fibroblasts.
关键词： PDE5 cardiac fibrosis TGF-β CREB
Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li
《医学前沿（英文）》 2020年 第14卷 第3期 页码 262-272 doi: 10.1007/s11684-019-0717-5
Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling
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《医学前沿（英文）》 2015年 第9卷 第4期 页码 444-456 doi: 10.1007/s11684-015-0421-z
Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and potential mechanism of aspirin have not been investigated in detail. In this study, healthy wild-type male mice were randomly divided into three groups and subjected to transverse aortic constriction (TAC) or sham operation. The TAC-operated mice were treated with the human equivalent of low-dose aspirin (10 mg·kg−1·d−1); the remaining mice received an equal amount of phosphate buffered saline with 0.65% ethanol, which was used as a vehicle. A cardiomyocyte hypertrophy model induced by angiotensin II (10 nmol·L−1) was treated with the human equivalent of low (10 or 100 µmol·L−1) and high (1000 µmol·L−1) aspirin concentrations in plasma. Changes in the cardiac structure and function were assessed through echocardiography and transmission electron microscopy. Gene expression was determined through RT-PCR and western blot analysis. Results indicated that aspirin treatment abrogated the increased thickness of the left ventricular anterior and posterior walls, the swelling of mitochondria, and the increased surface area in in vivo and in vitro hypertrophy models. Aspirin also normalized the upregulated hypertrophic biomarkers, β-myosin heavy chain (β-MHC), atrial natriuretic peptide (ANP), and b-type natriuretic peptide (BNP). Aspirin efficiently reversed the upregulation of β-catenin and P-Akt expression and the TAC- or ANG II-induced downregulation of GSK-3β. Therefore, low-dose aspirin possesses significant anti-hypertrophic properties at clinically relevant concentrations for anti-thrombotic therapy. The downregulation of β-catenin and Akt may be the underlying signaling mechanism of the effects of aspirin.
PAK1 is a novel cardiac protective signaling molecule
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《医学前沿（英文）》 2014年 第8卷 第4期 页码 399-403 doi: 10.1007/s11684-014-0380-9
We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase 1 (PAK1), a member of a serine/threonine protein kinase family. Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity is key in the regulation of a number of cellular functions, the role of PAK1 in the heart has only been revealed over the past few years. In this review, we assemble an overview of the recent findings on PAK1 signaling in the heart, particularly its cardiac protective effects. We present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellular processes in which regulation of protein phosphorylation states by protein phosphatase 2A (PP2A) predominates. We discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its role in maintaining ventricular Ca2+ homeostasis and electrophysiological stability under physiological, β-adrenergic and hypertrophic stress conditions.
FGF23 associated bone diseases
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《医学前沿（英文）》 2013年 第7卷 第1期 页码 65-80 doi: 10.1007/s11684-013-0254-6
Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease.
关键词： fibroblast growth factor 23 FGF receptor phosphate metabolism Klotho bone disease
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
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《医学前沿（英文）》 2013年 第7卷 第1期 页码 25-30 doi: 10.1007/s11684-013-0244-8
Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.
关键词： FGF21 metabolism pharmacology physiology clinical relevance
Right coronary occlusion following transcatheter aortic valve implantation: two case reports
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《医学前沿（英文）》 2016年 第10卷 第3期 页码 351-355 doi: 10.1007/s11684-016-0465-8
This paper discusses two male patients with severe aortic stenosis, whose right coronary arteries (RCA) were completely occluded during transcatheter aortic valve implantation (TAVI), leading to fatal hemodynamic disorder. Occlusions of RCA complicated by TAVI are rare. In addition, emergency cardiopulmonary bypass (CPB) played a critical role in rescuing our second patient. Both patients were admitted for “severe aortic stenosis,” and TAVIs were performed. The first patient’s blood pressure immediately dropped to 70/40 mmHg after the balloon expansion and did not increase much after the administration of aramine or fluid therapy. He did not receive emergency surgery and died after 1.5 h of resuscitation. The second patient’s blood pressure fluctuated greatly for several minutes after the valve implantation, ranging from 170/100 mmHg to 60/40 mmHg. Angiography revealed a total occlusion of RCA. Thoracic surgery with CPB was performed, and the patient survived.
关键词： aortic stenosis transcatheter aortic valve implantation right coronary occlusion cardiac group
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《医学前沿（英文）》 2016年 第10卷 第1期 页码 33-40 doi: 10.1007/s11684-016-0431-5
Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active biomolecules, including extracellular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.
关键词： cancer-associated fibroblast breast cancer progression prognosis
心肌远程调节及其临床相关性：现在一起来！ Review
Kristin Luther,Yang Song,Yang Wang,Xiaoping Ren,W. Keith Jones
《工程（英文）》 2015年 第1卷 第4期 页码 490-499 doi: 10.15302/J-ENG-2015117
急性心肌梗死(AMI) 是世界上致死和致残的主要病因。及时再灌注法是AMI的标准疗法，能够缩小梗死面积，提高患者存活率和改善预后。然而，25 %的患者在患心肌梗死(Ml) 后会进一步发展成为心力衰竭(HF)，且其中50%的患者会在5年内死亡。由于梗死面积是预断病人病情( 包括HF的形成) 的主要指标，因此，改善心肌的治疗方法具有极大的应用前景。 在过去30年中，研究者已发现多种能够刺激内源性心肌保护通道的刺激物，这些刺激物能在缺血预适应(IPC)和缺血后适应以及心肌缺血情况下启动保护机制。当在心肌缺血发生前、发生期间或发生后即刻使用刺激物，在远离心脏的血管床中发生的短暂、可逆性局部缺血就会即刻引发心肌保护机制——这种现象被分别称为远程缺血预适应，远程缺血期适应和远程缺血后适应。尽管目前的研究尚未完全阐明远程缺血预适应(RIPC) 的作用机制，但RIPC与IPC在机制上有很多共同之处。RIPC的发现使研究转向了远程非缺血刺激的应用，包括神经刺激( 脊髓刺激和迷走神经刺激) 以及电针(EA)。笔者与其他研究人员发现并阐述了非缺血现象的机制，并将其定义为远程创伤预适 应(RPCT)。通过刺激皮肤感觉神经来启动RPCT，这与穴位处神经刺激和EA既有相似性又有一定差异性。笔者在此次研究中还发现，可通过采用腹中线电刺激(与EA疗法相似) 来模拟RPCT，而且作为预适应刺激和后适应刺激( 在应用再灌注法时)，这种激活心肌保护机制的模式是非常有效的。通过对这些心肌保护现象的研究，学术界对心肌保护机制形成了一种全面且综 合的理解，而且在过去的5~10 年期间, 这种理解变得逐渐清晰，即无论是缺血性刺激诱导还是非缺血性刺激诱导，其机制均相似。通过对文献中多种数据的综合考虑，我们认为所有的这些心肌保护“适应”现象均表示心肌保护机制的启动是从心肌适 应网(含有特定介质和心肌细胞生存感受器) 的不同切入点进行的，该切入点包括NF-κB、Stat3/5、蛋白激酶C、舒缓激肽和mitoKATP 通道。神经系统传导通路可能代表了一种激活心脏和其他器官适应的新机制。研究表明，由于IPC和RIPC存在一定风险并且无法应用于某些患者，所以它们很难被转化为临床应用。因此，近期又新兴了一种神经刺激和痛感刺激的应用，这是一种激活心肌适应的潜在的非缺血性无创方法。作为引起心脏保护作用众多方法之一的后适应重点强调了临床相关性，这种临床相关性有助于在现有成熟的药物与电子疗法中加速新的治疗方向的突破。
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《医学前沿（英文）》 2017年 第11卷 第2期 页码 293-296 doi: 10.1007/s11684-017-0516-9
Familial amyloid cardiomyopathy is a challenging condition that mimics many other diseases, particularly in patients with pronounced neurological presentations and unexplained or equivocal cardiac abnormalities. In this case, a 57-year-old man was admitted for outpatient cardiological evaluation of progressive right heart failure and limb paraesthesias. The patient presented with hypertension, chronic Guillain-Barre syndrome, and sick sinus syndrome. Transthoracic echocardiograms showed a thickened ventricular wall and enlarged atrium. Tissue Doppler showed a restrictive filling pattern. Transthyretin (TTR)-associated amyloidosis, which was revealed by abdominal fat-pad biopsy and DNA analysis, explained the concurrence of independent pathological features, including neuropathy and cardiac involvement. Genetic testing identified a G>T mutation in exon 4 of the transthyretin (TTR) gene. This mutation resulted in the alanine-to-serine substitution at amino acid position 117. Moreover, genetic testing confirmed that the patient’s asymptomatic son carried the same amyloidogenic TTR mutation. Given these findings, the diagnosis of familial amyloid cardiomyopathy, which was misdiagnosed as chronic Guillain-Barre syndrome, was proposed.
关键词： transthyretin (TTR) cardiac amyloidosis sick sinus syndrome chronic Guillain-Barre syndrome
标题 作者 时间 类型 操作
Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in
期刊论文
Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients
期刊论文
Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
期刊论文
Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis
null
期刊论文
Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast
Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li
期刊论文
Right coronary occlusion following transcatheter aortic valve implantation: two case reports
null
期刊论文
Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications
null
期刊论文
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